Day 0: Friday, August 7. Registration as you arrive. Reception 19:00-20:30
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Day 1: Saturday, August 8, 1998

Transcription Factors Saturday Aug. 8
(Chair: Ghosh, Sankar, Kaltschmidt, Christian & Spandidos, Demetrios)

NF-kB Saturday Aug. 8
* Kaltschmidt, Christian (1998, 1999), PD, Molecular Neurobiology, Institute of Anatomy, Albert-Ludwigs-University of Freiburg, Germany: "Role of NF-kB in neuroprotection and cell cycle control" (25 min)
* Ghosh, Sankar, Associate Professor, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven CT: "Phosphorylation-dependent regulation of NF-kB transcriptional activity" (20 min)
* Sun, Shao-Cong, Assistant Professor, Pennsylvania State University College of Medicine, Hershey, PA: "NF-kB signaling triggered by the HTLV-I transactivator Tax" (20 min)

Nuclear Hormone Receptors Saturday Aug. 8
* Nardulli, Ann, Associate Professor University of Illinois at Urbana-Champaign, Urbana, IL: "Mechanisms involved in regulation of the estrogen-responsive pS2 gene" (20 min)

Viral transcription factors Saturday Aug. 8
* Andrisani, Ourania, Associate Professor, Purdue University, West Lafayette, IN: "CREB/HBx interactions as a model system for HBV-mediated hepatocarcinogenesis" (15 min)
* Vogel, Jodi, Senior Staff Fellow, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD: "Coordinated assembly at the HSV enhancer by the C1 factor" (15 min)

Regulatory DNA sequences Saturday Aug. 8
* Spandidos, Demetrios, Editor, Int J Oncol, Int J Mol Med and Oncol Rep, Professor, University of Crete: "Transcriptional regulation of the H-ras proto-oncogene by DNA-binding proteins"

Triplex DNA & Intrinsically curved DNA Saturday Aug. 8
* Van Dyke, Michael, Associate Professor, The University of Texas M. D. Anderson Cancer Center, Houston, TX: "Characterization of purine-motif triplex DNA-binding proteins in HeLa extracts" (15 min)
* Trifonov, Ed, The Weizmann Institute of Science, Rehovot, Israel: "Role of DNA curvature and of nucleosomes in 3D organization of regulatory regions" (25 min)

Basal transcription Saturday Aug. 8
* White, Robert, Lecturer, Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Scotland, UK: "RNA polymerase III transcription - A novel target for regulation by the tumour suppressors Rb and p53" (25 min)

Transcription factors in oncogenesis & differentiation Saturday Aug. 8
* Rangnekar, Vivek , Associate Professor, University of Kentucky, Lexington, KY: " Tumor cell apoptosis by the leucine zipper protein Par-4" (25 min)
* Ito, Yoshiaki, Professor, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto, Japan: "The Runt domain transcription factor, PEBP2/CBF: involvement in hematopoiesis and leukemogenesis"
* Shi, Yang, Associate Professor, Harvard Medical School, Boston MA: "Transcriptional cofactor p300 in differentiation"
* Sun, Xiao-Hong New York University Medical Center, New York, NY: "Role of basic helix-loop-helix proteins in cell differentiation and proliferation" (20 min)
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Day 2: Sunday, August 9, 1998
Excursion to the island of Santorini

Day 3: Monday, August 10, 1998

Chromatin Monday Aug. 10
(Chair: Althaus, Felix, Davie, James & Wolffe, Alan)
Histone acetylation Monday Aug. 10
* Davie, James, Professor and MRC Senior Scientist, University of Manitoba, Winnipeg, Canada: "Histone modifications and transcribed chromatin" (25 min)
* Richon, Victoria, Memorial Sloan-Kettering Cancer Center, New York, NY: "Histone acetylation and hybrid polar inducers of transformed cell differentiation" (20 min)

Transcription Factors and Nucleosomes Monday Aug. 10
* Wolffe, Alan, Chief, Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD: "Regulatory roles for chromatin" (25 min)
* DiRenzo, James, Dana Farber Cancer Institute, Boston, MA: "Recruitment of nucleosome remodeling factors by the steroid receptor coactivator-1 mediates estrogen receptor function" (15 min)
* Kladde, Michael, The Pennsylvania State University, University Park, PA and Department of Biochemistry and Biophysics at Texas A&M University in College Station: "Factor binding site position in nucleosomes influences in vivo chromatin remodeling and transcriptional activation" (20 min)

HMG Proteins Monday Aug. 10
* Thanos, Dimitris, Assistant Professor, Columbia University, New York: "Recruitement of CBP/p300 by the IFN-b enhanceosome directs synergistic activation of transcription and specific acetylation of the HMGI(Y) protein" (25 min).
* Jansen, Erik, Center for Human Genetics, University of Leuven, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium: "Involvement of the architectural transcription factor HMGI-C in benign tumor formation" (15 min)

Chromatin Inactivation/Polycomb Monday Aug. 10
* Kanno, Masamoto Department Head and Professor, School of Medicine, Hiroshima University, Japan: " Functional analysis of mammalian Polycomb group genes: involvement of mel-18 in regulation of cell cycle progression and subsequent maintenance/ cell death." (20 min)

Chromatin/Poly(ADP-ribosyl)ation Monday Aug. 10
* Althaus, Felix Director, Professor of Pharmacology & Toxicology, Institute of Pharmacology & Toxicology, Zürich, Switzerland: "Linkage of apoptotic proficiency, p53 response and morphological phenotype to a single gene: PARP" (25 min)
* Caiafa, Paola, Professor, Facolta di Medicina e Chirurgia, Universita degli Studi dell' Aquila, L' Aquila, Italy: "Anomalous methylation pattern of the CpG islands as a consequence of the poly(ADP-ribosyl)ation block" (20 min)
* Quesada, Piera, Professor, Universita degli Studi di Napoli Federico II, Napoli, Italy: "Poly(ADP-ribosyl)ation in meiotic rat germinal cells in response to genotoxic stress" (15 min)

Day 4: Tuesday, August 11, 1998

DNA Replication Tuesday Aug. 11
(Chair: Szyf, Moshe, McBride, Alison & Fisher, Paul)

* McBride, Alison, Investigator, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD: "Papillomavirus viral genomes and the E2 transactivator/replication protein are associated with mitotic chromosomes: a mechanism for genome segregation?" (25 min)
* Zorbas, Haralabos, Institut für Biochemie der Ludwig-Maximilians-Universität München, Germany: "A possible role for DNA structures in the initiation of eukaryotic DNA replication" (25 min)
* Mirkin, Sergei, Associate Professor, University of Illinois, Chicago, IL: "Replication through repeated DNA sequences" (25 min)
* Resnick, Michael Head, Chromosome Stability Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC: "Understanding genome stability through humanizing of yeast" (25 min)
* Fisher, Paul, Professor, Director, Medical Scientist Training Program, State University of New York, Stony Brook, NY: "PCNA, Mutagenesis and Carcinogenesis" (25 min)

DNA Methylation Tuesday Aug. 11
* Szyf, Moshe McGill University, Montreal, PQ, Canada: "The enzymes of the cytosine DNA methylation as anticancer targets" (25 min)

Free afternoon; visit the nearby ancient site of Knossos (Minoan Civilization) and the Archaeological Museum of Heraklion.

Day 5: Wednesday, August 12, 1998

Locus Control Regions Aug. 12
(Chair: Garrard, William & Wiginton, Dan)
* Wiginton, Dan University of Cincinnati, Children's Hospital Research Foundation, Cincinnati, OH: "Distinct enhancers/LCRs regulate adenosine deaminase in various tissues" (25 min)
* Bonifer, Constanze, University of Leeds, St James's Hospital, Molecular Medicine Unit, Leeds, UK: "The developmental activation of the lysozyme locus is a cooperative process" (25 min)

Nuclear matrix Aug. 12
(Chair: Garrard, William & Wiginton, Dan)
* Shulman, Marc Professor, Department of Immunology, University of Toronto, Toronto, Ontario, Canada: "Role of the enhancer and matrix attachment regions in the expression of the endogenous immunoglobulin heavy chain locus" (25 min)
* Boulikas, Teni, Senior Investigator, Institute of Molecular Medical Sciences, and President & CEO, Regulon, Inc., Palo Alto, CA: "Inverted repeats are signposts for MARs and other regulatory regions" (20 min)
* Gruenbaum, Yosef, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel: "The roles of the nuclear lamina in nuclear envelope assembly and chromatin organization" (25 min)
* Garrard, William Professor, Southwestern Medical School, Dallas, Texas: "The Kappa Immunoglobulin Gene MAR Regulates the Probability of Premature V-J Joining Negatively and Somatic Hypermutation Positively" (25 min)

Nuclear Import/Export and Cell Trafficking Aug. 12
(Chair: Sawadogo, Michèle)
* Moroianu, Junona, Assistant Professor, Boston College, Chestnut Hill, MA: "Molecular mechanisms of nucleocytoplasmic transport" (20 min)
* Arai, Naoko, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA: "Function of NFATx, a family of NFAT (Nuclear Factor of activated T cells)" (20 min)

Cell cycle control/ p53/RB Aug. 12
(Chair: Sawadogo, Michèle)
* Sawadogo, Michèle, The University of Texas M.D. Anderson Cancer Center, Houston, TX: "Role of transcription factor USF in growth control" (25 min)
* Kastanos, Evdokia, NCI-Navy Medicine Branch, National Naval Medical Center, Bethesda, MD: "Regulation of p53 levels by thymidylate synthase in vivo" (10 min)

Gala Dinner, 18:30-Midnight

Day 6: Thursday, August 13, 1998
Organized excursion to the Gorge of Samaria

Day 7: Friday, August 14, 1998

Phosphorylation/Signaling Aug. 14
(Chair: Haegeman, Guy, Rosner, Marsha & Kadesch, Tom)
* Rosner, Marsha, Chair, Committee on Cancer Biology, Professor, Ben May Institute for Cancer Research, University of Chicago, Chicago, IL: "Signal transduction cascades regulating neuronal cell differentiation" (25 min)
* Shapiro, Paul, Post-doctoral Fellow, University of Colorado, Boulder, CO: Regulation of cellular targets by the MAP kinase pathway" (25 min)
* Ostrowski, Mike, Associate Professor, The Ohio State University, Columbus, OH: "Phosphorylation of ets-2 by ras/raf signaling pathways and the regulation of transcription" (25 min)
* Birge, Raymond, Assistant Professor, The Rockefeller University, New York, NY: "Role of Crk in signal transduction from the nerve growth factor receptor"(20 min)
* Haegeman, Guy, Professor, Flanders Interuniversity Institute for Biotechnology, Vakgroep Moleculaire Biologie, University of Ghent, Belgium: "Tumor necrosis factor regulates interleukin-6 gene expression by a dual signaling pathway" (25 min)
* Wirth, T, Professor, Institut für Medizinische Strahlenkunde und Zellforschung, University of Würzburg, Germany: " " (25 min)
* Koromilas, Antonis, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada: "Regulation of cell growth and signaling by the IFN-inducible protein kinase PKR" (25 min)
* Manser, Ed, Senior Scientist, Glaxo-IMCB Laboratory Institute of Molecular and Cell Biology, Singapore: "Kinases interacting with Cdc42/Rac GTPases" (15 min)
* Yamamoto, Tadashi, Professor and Chief, Department of Oncology, University of Tokyo, Tokyo, Japan: "Regulation of glutamate receptors (both metabotropic and ionotropic) by tyrosine phosphorylation" (20 min)

Apoptosis/Cancer Aug. 14
(Chair: Haegeman, Guy, Rosner, Marsha & Kadesch, Tom)
* Kleinberger, Tamar, The B. Rappaport Faculty of Medicine, Technion, Haifa, Israel: "Induction of apoptosis in transformed cells by adenovirus E4orf4 protein"
* Sices, Harry, Graduate Student, NIH, Bethesda, MD: "A genetic screen for the isolation and characterization of site-specific proteases" (10 min)

Development Aug. 14
(Chair: Haegeman, Guy, Rosner, Marsha & Kadesch, Tom)
* Kadesch, Tom, Professor, Howard Hughes Medical Institute and Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA: "A Notch-eyed view of transcription in B cells" (20 min)
* Majumder, Sadhan, Assistant Professor, University of Texas MD Anderson Cancer Center, Houston, TX: " Lack of a coactivator activity required for enhancer function is unique to oocytes and fertilized eggs " (20 min)

Attendees (Transcription Conference)
* Reuning, Ute, Frauenklinik der TU München, Klinikum Rechts der Isar, Munich, Germany
* Zhang, Min-Yin, Instructor, Milton Hershey Medical Center, Hershey, PA
* Schuele, Roland, Klinik fuer Tumorbiologie, Freiburg, Germany: (20 min)

Day 8: Saturday, August 15: Organized one-day excursion to Hania